Ontology highlight
ABSTRACT:
SUBMITTER: Jiang Z
PROVIDER: S-EPMC4735990 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Jiang Zhi Z Liang Zhongjie Z Shen Bairong B Hu Guang G
BioMed research international 20151231
Pleckstrin homology (PH) domains share low sequence identities but extremely conserved structures. They have been found in many proteins for cellular signal-dependent membrane targeting by binding inositol phosphates to perform different physiological functions. In order to understand the sequence-structure relationship and binding specificities of PH domains, quantum mechanical (QM) calculations and sequence-based combined with structure-based binding analysis were employed in our research. In ...[more]