A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity.
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ABSTRACT:
SUBMITTER: Hasstedt SJ
PROVIDER: S-EPMC4736014 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity.
Hasstedt Sandra J SJ Xin Yuanpei Y Mao Rong R Lewis Tracey T Adams Ted D TD Hunt Steven C SC
Journal of obesity 20151231
<h4>Background/objectives</h4>To identify copy number variants (CNVs) which are associated with body mass index (BMI).<h4>Subjects/methods</h4>CNVs were identified using array comparative genomic hybridization (aCGH) on members of pedigrees ascertained through severely obese (BMI ≥ 35 kg/m(2)) sib pairs (86 pedigrees) and thin (BMI ≤ 23 kg/m(2)) probands (3 pedigrees). Association was inferred through pleiotropy of BMI with CNV log2 intensity ratio.<h4>Results</h4>A 77-kilobase CNV on chromosom ...[more]
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