Ontology highlight
ABSTRACT:
SUBMITTER: Huang YF
PROVIDER: S-EPMC4737051 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Huang Yan-Feng YF Lu Lu L Zhu Da-Jian DJ Wang Ming M Yin Yi Y Chen De-Xiu DX Wei Lian-Bo LB
Oxidative medicine and cellular longevity 20160111
This paper studied the chronic fatigue induced by excessive exercise and the restoration effects of Astragalus polysaccharides (APS) on mitochondria. In vivo, we found that excessive exercise could cause oxidative stress statue which led to morphological and functional changes of mitochondria. The changes, including imbalance between mitochondria fusion-fission processes, activation of mitophagy, and decrease of PGC-1α expression, could be restored by APS. We further confirmed in vitro, and what ...[more]