Dataset Information

Utility of 3D multimodality imaging in the implantation of intracranial electrodes in epilepsy.

ABSTRACT:

Objective

We present a single-center prospective study, validating the use of 3D multimodality imaging (3 DMMI) in patients undergoing intracranial electroencephalography (IC-EEG).

Methods

IC-EEG implantation preparation entails first designing of the overall strategy of implantation (strategy) and second the precise details of implantation (planning). For each case, the multidisciplinary team made decisions on strategy and planning before the disclosure of multimodal brain imaging models. Any changes to decisions, following disclosure of the multimodal models, were recorded.

Results

Disclosure of 3 DMMI led to a change in strategy in 15 (34%) of 44 individuals. The changes included addition and subtraction of electrodes, addition of grids, and going directly to resection. For the detailed surgical planning, 3 DMMI led to a change in 35 (81%) of 43 individuals. Twenty-five (100%) of 25 patients undergoing stereo-EEG (SEEG) underwent a change in electrode placement, with 158 (75%) of 212 electrode trajectories being altered.

Significance

The use of 3 DMMI makes substantial changes in clinical decision making.

SUBMITTER: Nowell M

PROVIDER: S-EPMC4737214 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Publications

Utility of 3D multimodality imaging in the implantation of intracranial electrodes in epilepsy.

Nowell Mark M Rodionov Roman R Zombori Gergely G Sparks Rachel R Winston Gavin G Kinghorn Jane J Diehl Beate B Wehner Tim T Miserocchi Anna A McEvoy Andrew W AW Ourselin Sebastien S Duncan John J

Epilepsia 20150205 3

<h4>Objective</h4>We present a single-center prospective study, validating the use of 3D multimodality imaging (3 DMMI) in patients undergoing intracranial electroencephalography (IC-EEG).<h4>Methods</h4>IC-EEG implantation preparation entails first designing of the overall strategy of implantation (strategy) and second the precise details of implantation (planning). For each case, the multidisciplinary team made decisions on strategy and planning before the disclosure of multimodal brain imagin ...[more]

PMID: 25656379

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Project description:IntroductionAlthough deep brain stimulation is nowadays performed worldwide, the biomechanical aspects of electrode implantation received little attention, mainly as physicians focused on the medical aspects, such as the optimal indication of the surgical procedure, the positive and adverse effects, and the long-term follow-up. We aimed to describe electrode deformations and brain shift immediately after implantation, as it may highlight our comprehension of intracranial and intracerebral mechanics.Materials and methodsSixty electrodes of 30 patients suffering from severe symptoms of Parkinson's disease and essential tremor were studied. They consisted of 30 non-directional electrodes and 30 directional electrodes, implanted 42 times in the subthalamus and 18 times in the ventrolateral thalamus. We computed the x (transversal), y (anteroposterior), z (depth), torsion, and curvature deformations, along the electrodes from the entrance point in the braincase. The electrodes were modelized from the immediate postoperative CT scan using automatic voxel thresholding segmentation, manual subtraction of artifacts, and automatic skeletonization. The deformation parameters were computed from the curve of electrodes using a third-order polynomial regression. We studied these deformations according to the type of electrodes, the clinical parameters, the surgical-related accuracy, the brain shift, the hemisphere and three tissue layers, the gyration layer, the white matter stem layer, and the deep brain layer (type I error set at 5%).ResultsWe found that the implanted first hemisphere coupled to the brain shift and the stiffness of the type of electrode impacted on the electrode deformations. The deformations were also different according to the tissue layers, to the electrode type, and to the first-hemisphere-brain-shift effect.ConclusionOur findings provide information on the intracranial and brain biomechanics and should help further developments on intracerebral electrode design and surgical issues.

Dataset Information

Utility of 3D multimodality imaging in the implantation of intracranial electrodes in epilepsy.

Objective

Methods

Results

Significance

Publications

Utility of 3D multimodality imaging in the implantation of intracranial electrodes in epilepsy.

Similar Datasets

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