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Sensory Deviancy Detection Measured Directly Within the Human Nucleus Accumbens.

ABSTRACT: Rapid changes in the environment evoke a comparison between expectancy and actual outcome to inform optimal subsequent behavior. The nucleus accumbens (NAcc), a key interface between the hippocampus and neocortical regions, is a candidate region for mediating this comparison. Here, we report event-related potentials obtained from the NAcc using direct intracranial recordings in 5 human participants while they listened to trains of auditory stimuli differing in their degree of deviation from repetitive background stimuli. NAcc recordings revealed an early mismatch signal (50-220 ms) in response to all deviants. NAcc activity in this time window was also sensitive to the statistics of stimulus deviancy, with larger amplitudes as a function of the level of deviancy. Importantly, this NAcc mismatch signal also predicted generation of longer latency scalp potentials (300-400 ms). The results provide direct human evidence that the NAcc is a key component of a network engaged in encoding statistics of the sensory environmental.

SUBMITTER: Durschmid S 

PROVIDER: S-EPMC4737607 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Sensory Deviancy Detection Measured Directly Within the Human Nucleus Accumbens.

Dürschmid Stefan S   Zaehle Tino T   Hinrichs Hermann H   Heinze Hans-Jochen HJ   Voges Jürgen J   Garrido Marta I MI   Dolan Raymond J RJ   Knight Robert T RT  

Cerebral cortex (New York, N.Y. : 1991) 20150109 3

Rapid changes in the environment evoke a comparison between expectancy and actual outcome to inform optimal subsequent behavior. The nucleus accumbens (NAcc), a key interface between the hippocampus and neocortical regions, is a candidate region for mediating this comparison. Here, we report event-related potentials obtained from the NAcc using direct intracranial recordings in 5 human participants while they listened to trains of auditory stimuli differing in their degree of deviation from repe  ...[more]