Ontology highlight
ABSTRACT:
SUBMITTER: Korpela K
PROVIDER: S-EPMC4737757 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Korpela Katri K Salonen Anne A Virta Lauri J LJ Kekkonen Riina A RA Forslund Kristoffer K Bork Peer P de Vos Willem M WM
Nature communications 20160126
Early-life antibiotic use is associated with increased risk for metabolic and immunological diseases, and mouse studies indicate a causal role of the disrupted microbiome. However, little is known about the impacts of antibiotics on the developing microbiome of children. Here we use phylogenetics, metagenomics and individual antibiotic purchase records to show that macrolide use in 2-7 year-old Finnish children (N=142; sampled at two time points) is associated with a long-lasting shift in microb ...[more]