Ontology highlight
ABSTRACT:
SUBMITTER: Mori S
PROVIDER: S-EPMC4738070 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Biochemistry 20160119 4
The azinomycins are a family of potent antitumor agents with the ability to form interstrand cross-links with DNA. This study reports on the unusual biosynthetic formation of the 5-methyl naphthoate moiety, which is essential for effective DNA association. While sequence analysis predicts that the polyketide synthase (AziB) catalyzes the formation of this naphthoate, 2-methylbenzoic acid, a truncated single-ring product, is formed instead. We demonstrate that the thioesterase (AziG) acts as a ch ...[more]