Early rescue of interneuron disease trajectory in developmental epilepsies.
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ABSTRACT:
SUBMITTER: Siehr MS
PROVIDER: S-EPMC4738159 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Early rescue of interneuron disease trajectory in developmental epilepsies.
Siehr Meagan S MS Noebels Jeffrey L JL
Current opinion in neurobiology 20151027
The discovery of over 150 monogenic epilepsies and advances in early genetic diagnoses have launched a search for molecular strategies and developmental timetables to reverse or even prevent the course of these debilitating brain disorders. Orthologous rodent models of key disease genes are providing important examples of the range of targets, and serve as valuable test systems for perinatal therapeutic approaches. While gene-specific analyses of single rare 'orphan' diseases are each narrow in ...[more]
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