Ontology highlight
ABSTRACT:
SUBMITTER: Korwitz A
PROVIDER: S-EPMC4738383 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Korwitz Anne A Merkwirth Carsten C Richter-Dennerlein Ricarda R Tröder Simon E SE Sprenger Hans-Georg HG Quirós Pedro M PM López-Otín Carlos C Rugarli Elena I EI Langer Thomas T
The Journal of cell biology 20160101 2
Proteolytic cleavage of the dynamin-like guanosine triphosphatase OPA1 in mitochondria is emerging as a central regulatory hub that determines mitochondrial morphology under stress and in disease. Stress-induced OPA1 processing by OMA1 triggersmitochondrial fragmentation, which is associated with mitophagy and apoptosis in vitro. Here, we identify OMA1 as a critical regulator of neuronal survival in vivo and demonstrate that stress-induced OPA1 processing by OMA1 promotes neuronal death and neur ...[more]