Independent Control of Topography for 3D Patterning of the ECM Microenvironment.
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ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC4738476 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Independent Control of Topography for 3D Patterning of the ECM Microenvironment.
Kim Jiyun J Staunton Jack Rory JR Tanner Kandice K
Advanced materials (Deerfield Beach, Fla.) 20151109 1
Biomimetic extracellular matrix (ECM) topographies driven by the magnetic-field-directed self-assembly of ECM protein-coated magnetic beads are fabricated. This novel bottom-up method allows us to program isotropic, anisotropic, and diverse hybrid ECM patterns without changing other physicochemical properties of the scaffold material. It is demonstrated that this 3D anisotropic matrix is able to guide the dendritic protrusion of cells. ...[more]
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