Ontology highlight
ABSTRACT:
SUBMITTER: Wojcik P
PROVIDER: S-EPMC4739084 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Wojcik P P Jasiowka M M Strycharz E E Sobol M M Hodorowicz-Zaniewska D D Skotnicki P P Byrski T T Blecharz P P Marczyk E E Cedrych I I Jakubowicz J J Lubiński J J Sopik V V Narod S S Pierzchalski P P
Hereditary cancer in clinical practice 20160203
<h4>Background</h4>Mutations in the BRCA1, BRCA2 and PALB2 genes are well-established risk factors for the development of breast and/or ovarian cancer. The frequency and spectrum of mutations in these genes has not yet been examined in the population of Southern Poland.<h4>Methods</h4>We examined the entire coding sequences of the BRCA1 and BRCA2 genes and genotyped a recurrent mutation of the PALB2 gene (c.509_510delGA) in 121 women with familial and/or early-onset breast or ovarian cancer from ...[more]