Ontology highlight
ABSTRACT:
SUBMITTER: Richard J
PROVIDER: S-EPMC4739418 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Richard Jonathan J Veillette Maxime M Ding Shilei S Zoubchenok Daria D Alsahafi Nirmin N Coutu Mathieu M Brassard Nathalie N Park Jongwoo J Courter Joel R JR Melillo Bruno B Smith Amos B AB Shaw George M GM Hahn Beatrice H BH Sodroski Joseph J Kaufmann Daniel E DE Finzi Andrés A
EBioMedicine 20151209
Human immunodeficiency virus type 1 (HIV-1) infection causes a progressive depletion of CD4 + T cells. Despite its importance for HIV-1 pathogenesis, the precise mechanisms underlying CD4 + T-cell depletion remain incompletely understood. Here we make the surprising observation that antibody-dependent cell-mediated cytotoxicity (ADCC) mediates the death of uninfected bystander CD4 + T cells in cultures of HIV-1-infected cells. While HIV-1-infected cells are protected from ADCC by the action of t ...[more]