Ontology highlight
ABSTRACT:
SUBMITTER: Richard J
PROVIDER: S-EPMC4739418 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
EBioMedicine 20151209
Human immunodeficiency virus type 1 (HIV-1) infection causes a progressive depletion of CD4 + T cells. Despite its importance for HIV-1 pathogenesis, the precise mechanisms underlying CD4 + T-cell depletion remain incompletely understood. Here we make the surprising observation that antibody-dependent cell-mediated cytotoxicity (ADCC) mediates the death of uninfected bystander CD4 + T cells in cultures of HIV-1-infected cells. While HIV-1-infected cells are protected from ADCC by the action of t ...[more]