Ontology highlight
ABSTRACT:
SUBMITTER: Hattermann K
PROVIDER: S-EPMC4739769 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
eLife 20160121
The transmembrane chemokines CX3CL1/fractalkine and CXCL16 are widely expressed in different types of tumors, often without an appropriate expression of their classical receptors. We observed that receptor-negative cancer cells could be stimulated by the soluble chemokines. Searching for alternative receptors we detected that all cells expressing or transfected with transmembrane chemokine ligands bound the soluble chemokines with high affinity and responded by phosphorylation of intracellular k ...[more]