Ontology highlight
ABSTRACT:
SUBMITTER: Mates JM
PROVIDER: S-EPMC4739806 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Mates Jessica M JM de Silva Suresh S Lustberg Mark M Van Deusen Kelsey K Baiocchi Robert A RA Wu Li L Kwiek Jesse J JJ
Retrovirology : research and treatment 20151015
Human immunodeficiency virus type 1 (HIV-1) latency is a major barrier to a cure of AIDS. Latently infected cells harbor an integrated HIV-1 genome but are not actively producing HIV-1. Histone deacetylase (HDAC) inhibitors, such as vorinostat (SAHA), have been shown to reactivate latent HIV-1. AR-42, a modified HDAC inhibitor, has demonstrated efficacy against malignant melanoma, meningioma, and acute myeloid leukemia and is currently used in clinical trials for non-Hodgkin's lymphoma and multi ...[more]