Ontology highlight
ABSTRACT:
SUBMITTER: Bisaria N
PROVIDER: S-EPMC4739851 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Biochemical Society transactions 20150401 2
Structured RNA molecules play roles in central biological processes and understanding the basic forces and features that govern RNA folding kinetics and thermodynamics can help elucidate principles that underlie biological function. Here we investigate one such feature, the specific interaction of monovalent cations with a structured RNA, the P4-P6 domain of the Tetrahymena ribozyme. We employ single molecule FRET (smFRET) approaches as these allow determination of folding equilibrium and rate c ...[more]