Ontology highlight
ABSTRACT:
SUBMITTER: Halene TB
PROVIDER: S-EPMC4740223 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Halene Tobias B TB Kozlenkov Alexey A Jiang Yan Y Mitchell Amanda C AC Javidfar Behnam B Dincer Aslihan A Park Royce R Wiseman Jennifer J Croxson Paula L PL Giannaris Eustathia Lela EL Hof Patrick R PR Roussos Panos P Dracheva Stella S Hemby Scott E SE Akbarian Schahram S
Schizophrenia research 20160106 2-3
Increased neuronal densities in subcortical white matter have been reported for some cases with schizophrenia. The underlying cellular and molecular mechanisms remain unresolved. We exposed 26 young adult macaque monkeys for 6 months to either clozapine, haloperidol or placebo and measured by structural MRI frontal gray and white matter volumes before and after treatment, followed by observer-independent, flow-cytometry-based quantification of neuronal and non-neuronal nuclei and molecular finge ...[more]