Ontology highlight
ABSTRACT:
SUBMITTER: Yaddanapudi K
PROVIDER: S-EPMC4740231 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Yaddanapudi Kavitha K Rendon Beatriz E BE Lamont Gwyneth G Kim Eun Jung EJ Al Rayyan Numan N Richie Jamaal J Albeituni Sabrin S Waigel Sabine S Wise Ashley A Mitchell Robert A RA
Cancer immunology research 20151124 2
Highly aggressive cancers "entrain" innate and adaptive immune cells to suppress antitumor lymphocyte responses. Circulating myeloid-derived suppressor cells (MDSC) constitute the bulk of monocytic immunosuppressive activity in late-stage melanoma patients. Previous studies revealed that monocyte-derived macrophage migration inhibitory factor (MIF) is necessary for the immunosuppressive function of tumor-associated macrophages and MDSCs in mouse models of melanoma. In the current study, we sough ...[more]