Dataset Information

Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium.

ABSTRACT:

Background

The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention.

Methods

We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD.

Findings

Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%quit_for_5-9 years to 89%quit_for_? 20 years declined SCLC risk vs. subjects who had quit smoking < 5 years. Compared with non-COPD subjects, smoking behaviors showed a significantly higher effect on SCLC risk among COPD subjects, and further, COPD patients showed a 1.86-fold higher risk of SCLC. Furthermore, smoking behaviors on SCLC risk were significantly mediated through COPD which accounted for 0.70% to 7.55% of total effects.

Interpretation

This is the largest pooling study that provides improved understanding of smoking on SCLC, and further demonstrates a causal pathway through COPD that warrants further experimental study.

SUBMITTER: Huang R

PROVIDER: S-EPMC4740296 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Publications

Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium.

Huang Ruyi R Wei Yongyue Y Hung Rayjean J RJ Liu Geoffrey G Su Li L Zhang Ruyang R Zong Xuchen X Zhang Zuo-Feng ZF Morgenstern Hal H Brüske Irene I Heinrich Joachim J Hong Yun-Chul YC Kim Jin Hee JH Cote Michele M Wenzlaff Angela A Schwartz Ann G AG Stucker Isabelle I Mclaughlin John J Marcus Michael W MW Davies Michael P A MP Liloglou Triantafillos T Field John K JK Matsuo Keitaro K Barnett Matt M Thornquist Mark M Goodman Gary G Wang Yi Y Chen Size S Yang Ping P Duell Eric J EJ Andrew Angeline S AS Lazarus Philip P Muscat Joshua J Woll Penella P Horsman Janet J Teare M Dawn MD Flugelman Anath A Rennert Gad G Zhang Yan Y Brenner Hermann H Stegmaier Christa C van der Heijden Erik H F M EH Aben Katja K Kiemeney Lambertus L Barros-Dios Juan J Pérez-Ríos Monica M Ruano-Ravina Alberto A Caporaso Neil E NE Bertazzi Pier Alberto PA Landi Maria Teresa MT Dai Juncheng J Hongbing Shen Hongbing H Fernandez-Tardon Guillermo G Rodriguez-Suarez Marta M Tardon Adonina A Christiani David C DC

EBioMedicine 20151101 11

<h4>Background</h4>The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention.<h4>Methods</h4>We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD.<h4>Findings</h4>Significa ...[more]

PMID: 26870794

Similar Datasets

Project description:BackgroundGenome-wide association studies have identified three chromosomal regions at 15q25, 5p15, and 6p21 as being associated with the risk of lung cancer. To confirm these associations in independent studies and investigate heterogeneity of these associations within specific subgroups, we conducted a coordinated genotyping study within the International Lung Cancer Consortium based on independent studies that were not included in previous genome-wide association studies.MethodsGenotype data for single-nucleotide polymorphisms at chromosomes 15q25 (rs16969968, rs8034191), 5p15 (rs2736100, rs402710), and 6p21 (rs2256543, rs4324798) from 21 case-control studies for 11 645 lung cancer case patients and 14 954 control subjects, of whom 85% were white and 15% were Asian, were pooled. Associations between the variants and the risk of lung cancer were estimated by logistic regression models. All statistical tests were two-sided.ResultsAssociations between 15q25 and the risk of lung cancer were replicated in white ever-smokers (rs16969968: odds ratio [OR] = 1.26, 95% confidence interval [CI] = 1.21 to 1.32, P(trend) = 2 x 10(-26)), and this association was stronger for those diagnosed at younger ages. There was no association in never-smokers or in Asians between either of the 15q25 variants and the risk of lung cancer. For the chromosome 5p15 region, we confirmed statistically significant associations in whites for both rs2736100 (OR = 1.15, 95% CI = 1.10 to 1.20, P(trend) = 1 x 10(-10)) and rs402710 (OR = 1.14, 95% CI = 1.09 to 1.19, P(trend) = 5 x 10(-8)) and identified similar associations in Asians (rs2736100: OR = 1.23, 95% CI = 1.12 to 1.35, P(trend) = 2 x 10(-5); rs402710: OR = 1.15, 95% CI = 1.04 to 1.27, P(trend) = .007). The associations between the 5p15 variants and lung cancer differed by histology; odds ratios for rs2736100 were highest in adenocarcinoma and for rs402710 were highest in adenocarcinoma and squamous cell carcinomas. This pattern was observed in both ethnic groups. Neither of the two variants on chromosome 6p21 was associated with the risk of lung cancer.ConclusionsIn this international genetic association study of lung cancer, previous associations found in white populations were replicated and new associations were identified in Asian populations. Future genetic studies of lung cancer should include detailed stratification by histology.

Dataset Information

Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium.

Background

Methods

Findings

Interpretation

Publications

Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium.

Similar Datasets

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