Network-based in silico drug efficacy screening.
Ontology highlight
ABSTRACT:
SUBMITTER: Guney E
PROVIDER: S-EPMC4740350 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Network-based in silico drug efficacy screening.
Guney Emre E Menche Jörg J Vidal Marc M Barábasi Albert-László AL
Nature communications 20160201
The increasing cost of drug development together with a significant drop in the number of new drug approvals raises the need for innovative approaches for target identification and efficacy prediction. Here, we take advantage of our increasing understanding of the network-based origins of diseases to introduce a drug-disease proximity measure that quantifies the interplay between drugs targets and diseases. By correcting for the known biases of the interactome, proximity helps us uncover the the ...[more]
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