Myocardial Structural and Biological Anomalies Induced by High Fat Diet in Psammomys obesus Gerbils.

ABSTRACT:

Background

Psammomys obesus gerbils are particularly prone to develop diabetes and obesity after brief period of abundant food intake. A hypercaloric high fat diet has been shown to affect cardiac function. Here, we sought to determine whether a short period of high fat feeding might alter myocardial structure and expression of calcium handling proteins in this particular strain of gerbils.

Methods

Twenty Psammomys obesus gerbils were randomly assigned to receive a normal plant diet (controls) or a high fat diet. At baseline and 16-week later, body weight, plasma biochemical parameters (including lipid and carbohydrate levels) were evaluated. Myocardial samples were collected for pathobiological evaluation.

Results

Sixteen-week high fat dieting resulted in body weight

SUBMITTER: Sahraoui A 

PROVIDER: S-EPMC4740502 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature