Ontology highlight
ABSTRACT:
SUBMITTER: Tang R
PROVIDER: S-EPMC4740766 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Tang Ruqi R Wei Yiran Y Li Zhiqiang Z Chen Haoyan H Miao Qi Q Bian Zhaolian Z Zhang Haiyan H Wang Qixia Q Wang Zhaoyue Z Lian Min M Yang Fan F Jiang Xiang X Yang Yue Y Li Enling E Seldin Michael F MF Gershwin M Eric ME Liao Wilson W Shi Yongyong Y Ma Xiong X
Scientific reports 20160204
Primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, has been associated with increased incidence of osteoporosis. Intriguingly, two PBC susceptibility loci identified through genome-wide association studies are also involved in bone mineral density (BMD). These observations led us to investigate the genetic variants shared between PBC and BMD. We evaluated 72 genome-wide significant BMD SNPs for association with PBC using two European GWAS data sets (n = 8392), with replication ...[more]