Joint mouse-human phenome-wide association to test gene function and disease risk.
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ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4740880 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Joint mouse-human phenome-wide association to test gene function and disease risk.
Wang Xusheng X Pandey Ashutosh K AK Mulligan Megan K MK Williams Evan G EG Mozhui Khyobeni K Li Zhengsheng Z Jovaisaite Virginija V Quarles L Darryl LD Xiao Zhousheng Z Huang Jinsong J Capra John A JA Chen Zugen Z Taylor William L WL Bastarache Lisa L Niu Xinnan X Pollard Katherine S KS Ciobanu Daniel C DC Reznik Alexander O AO Tishkov Artem V AV Zhulin Igor B IB Peng Junmin J Nelson Stanley F SF Denny Joshua C JC Auwerx Johan J Lu Lu L Williams Robert W RW
Nature communications 20160202
Phenome-wide association is a novel reverse genetic strategy to analyze genome-to-phenome relations in human clinical cohorts. Here we test this approach using a large murine population segregating for ∼5 million sequence variants, and we compare our results to those extracted from a matched analysis of gene variants in a large human cohort. For the mouse cohort, we amassed a deep and broad open-access phenome consisting of ∼4,500 metabolic, physiological, pharmacological and behavioural traits, ...[more]
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