Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.
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ABSTRACT:
SUBMITTER: Shouval DS
PROVIDER: S-EPMC4741283 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.
Shouval Dror S DS Ouahed Jodie J Biswas Amlan A Goettel Jeremy A JA Horwitz Bruce H BH Klein Christoph C Muise Aleixo M AM Snapper Scott B SB
Advances in immunology 20140101
Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation. Similarly, patients with deleterious mutations in IL10, IL10RA, or IL10RB present with severe enterocolitis within the first months of life. Here, we review recent fi ...[more]
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