Ontology highlight
ABSTRACT:
SUBMITTER: Strizzi L
PROVIDER: S-EPMC4741437 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Strizzi Luigi L Sandomenico Annamaria A Margaryan Naira V NV Focà Annalia A Sanguigno Luca L Bodenstine Thomas M TM Chandler Grace S GS Reed David W DW Gilgur Alina A Seftor Elisabeth A EA Seftor Richard E B RE Khalkhali-Ellis Zhila Z Leonardi Antonio A Ruvo Menotti M Hendrix Mary J C MJ
Oncotarget 20151001 33
Nodal is highly expressed in various human malignancies, thus supporting the rationale for exploring Nodal as a therapeutic target. Here, we describe the effects of a novel monoclonal antibody (mAb), 3D1, raised against human Nodal. In vitro treatment of C8161 human melanoma cells with 3D1 mAb shows reductions in anchorage-independent growth and vasculogenic network formation. 3D1 treated cells also show decreases of Nodal and downstream signaling molecules, P-Smad2 and P-ERK and of P-H3 and Cyc ...[more]