Ontology highlight
ABSTRACT:
SUBMITTER: Nkuipou-Kenfack E
PROVIDER: S-EPMC4741439 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Nkuipou-Kenfack Esther E Bhat Akshay A Klein Julie J Jankowski Vera V Mullen William W Vlahou Antonia A Dakna Mohammed M Koeck Thomas T Schanstra Joost P JP Zürbig Petra P Rudolph Karl L KL Schumacher Björn B Pich Andreas A Mischak Harald H
Oncotarget 20151001 33
To assess normal and pathological peptidomic changes that may lead to an improved understanding of molecular mechanisms underlying ageing, urinarypeptidomes of 1227 healthy and 10333 diseased individuals between 20 and 86 years of age were investigated. The diseases thereby comprised diabetes mellitus, renal and cardiovascular diseases. Using age as a continuous variable, 116 peptides were identified that significantly (p < 0.05; |ρ|≥0.2) correlated with age in the healthy cohort. The same appro ...[more]