Ontology highlight
ABSTRACT:
SUBMITTER: Rigiracciolo DC
PROVIDER: S-EPMC4741443 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Rigiracciolo Damiano Cosimo DC Scarpelli Andrea A Lappano Rosamaria R Pisano Assunta A Santolla Maria Francesca MF De Marco Paola P Cirillo Francesca F Cappello Anna Rita AR Dolce Vincenza V Belfiore Antonino A Maggiolini Marcello M De Francesco Ernestina Marianna EM
Oncotarget 20151001 33
Copper promotes tumor angiogenesis, nevertheless the mechanisms involved remain to be fully understood. We have recently demonstrated that the G-protein estrogen receptor (GPER) cooperates with hypoxia inducible factor-1α (HIF-1α) toward the regulation of the pro-angiogenic factor VEGF. Here, we show that copper sulfate (CuSO4) induces the expression of HIF-1α as well as GPER and VEGF in breast and hepatic cancer cells through the activation of the EGFR/ERK/c-fos transduction pathway. Worthy, th ...[more]