Ontology highlight
ABSTRACT:
SUBMITTER: Vallabhapurapu SD
PROVIDER: S-EPMC4741459 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Vallabhapurapu Subrahmanya D SD Blanco Víctor M VM Sulaiman Mahaboob K MK Vallabhapurapu Swarajya Lakshmi SL Chu Zhengtao Z Franco Robert S RS Qi Xiaoyang X
Oncotarget 20151001 33
Viable cancer cells expose elevated levels of phosphatidylserine (PS) on the exoplasmic face of the plasma membrane. However, the mechanisms leading to elevated PS exposure in viable cancer cells have not been defined. We previously showed that externalized PS may be used to monitor, target and kill tumor cells. In addition, PS on tumor cells is recognized by macrophages and has implications in antitumor immunity. Therefore, it is important to understand the molecular details of PS exposure on c ...[more]