Ontology highlight
ABSTRACT:
SUBMITTER: Guo C
PROVIDER: S-EPMC4741461 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Guo Cong C Su Jia J Li Zhijun Z Xiao Rui R Wen Jianxun J Li Yanyan Y Zhang Meng M Zhang Xueting X Yu Donna D Huang Wendong W Chen Wei-Dong WD Wang Yan-Dong YD
Oncotarget 20151001 33
Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. Here we show that TGR5 is a suppressor of gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway. We firstly show that TGR5 activation greatly inhibited proliferation and migration of human gastric cancer cells and strongly induced gastric cancer cell apoptosis. We then found that TGR5 activation antagonized STAT3 signal ...[more]