Ontology highlight
ABSTRACT:
SUBMITTER: Vlenterie M
PROVIDER: S-EPMC4741482 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Vlenterie Myrella M Hillebrandt-Roeffen Melissa H S MH Flucke Uta E UE Groenen Patricia J T A PJ Tops Bastiaan B J BB Tops Bastiaan B J BB Kamping Eveline J EJ Pfundt Rolph R de Bruijn Diederik R H DR Geurts van Kessel Ad H M AH van Krieken Han J H J M HJ van der Graaf Winette T A WT Versleijen-Jonkers Yvonne M H YM
Oncotarget 20151001 33
Over 95% of all synovial sarcomas (SS) share a unique translocation, t(X;18), however, they show heterogeneous clinical behavior. We analyzed multiple SS to reveal additional genetic alterations besides the translocation. Twenty-six SS from 22 patients were sequenced for 409 cancer-related genes using the Comprehensive Cancer Panel (Life Technologies, USA) on an Ion Torrent platform. The detected variants were verified by Sanger sequencing and compared to matched normal DNAs. Copy number variati ...[more]