Ontology highlight
ABSTRACT:
SUBMITTER: Donovan RM
PROVIDER: S-EPMC4741515 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Donovan Rory M RM Tapia Jose-Juan JJ Sullivan Devin P DP Faeder James R JR Murphy Robert F RF Dittrich Markus M Zuckerman Daniel M DM
PLoS computational biology 20160204 2
The long-term goal of connecting scales in biological simulation can be facilitated by scale-agnostic methods. We demonstrate that the weighted ensemble (WE) strategy, initially developed for molecular simulations, applies effectively to spatially resolved cell-scale simulations. The WE approach runs an ensemble of parallel trajectories with assigned weights and uses a statistical resampling strategy of replicating and pruning trajectories to focus computational effort on difficult-to-sample reg ...[more]