Ontology highlight
ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC4741582 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Wang Tong T Yuan Jie J Zhang Jie J Tian Ran R Ji Wei W Zhou Yan Y Yang Yi Y Song Weijie W Zhang Fei F Niu Ruifang R
Oncotarget 20151001 31
Overexpression of annexin A2 (Anxa2) is correlated with invasion and metastasis in breast cancer cells. In this study, breast cancer patients with upregulated Anxa2 exhibited poor overall and disease-free survival rates. Anxa2 expression was also positively correlated with the expression of epidermal growth factor receptor (EGFR) and epithelial-mesenchymal transition (EMT) markers in breast cancer tissues and cell lines. Moreover, knockdown of Anxa2 impaired EGF-induced EMT, as well as the migra ...[more]