Ontology highlight
ABSTRACT:
SUBMITTER: Serrano-Heras G
PROVIDER: S-EPMC4741604 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Serrano-Heras Gemma G Cuenca-López María Dolores MD Montero Juan Carlos JC Corrales-Sanchez Verónica V Morales Jorge Carlos JC Núñez Luz-Elena LE Morís Francisco F Pandiella Atanasio A Ocaña Alberto A
Oncotarget 20151001 31
Protein kinases play a central role in the oncogenesis of colorectal tumors and are attractive druggable targets. Detection of activated kinases within a tumor could open avenues for drug selection and optimization of new kinase inhibitors. By using a phosphokinase arrays with human colorectal tumors we identified activated kinases, including the Epidermal Growth Factor Receptor (EGFR), components of the PI3K/mTOR pathway (AKT and S6), and STAT, among others. A pharmacological screening with kin ...[more]