Ontology highlight
ABSTRACT:
SUBMITTER: Kim BR
PROVIDER: S-EPMC4741643 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Kim Boh-Ram BR Seo Seung Hee SH Park Mi Sun MS Lee Seung-Hoon SH Kwon Youngjoo Y Rho Seung Bae SB
Oncotarget 20151001 31
The suppressor of MEK null (sMEK1) protein possesses pro-apoptotic activities. In the current study, we reveal that sMEK1 functions as a novel anti-angiogenic factor by suppressing vascular endothelial growth factor (VEGF)-induced cell proliferation, migration, and capillary-like tubular structure in vitro. In addition, sMEK1 inhibited the phosphorylation of the signaling components up- and downstream of Akt, including phospholipase Cγ1 (PLC-γ1), 3-phosphoinositide-dependent protein kinase 1 (PD ...[more]