Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice.
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SUBMITTER: Weber H
PROVIDER: S-EPMC4741647 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
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Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice.
Weber Helga H Leal Pamela P Stein Stefan S Kunkel Hana H García Patricia P Bizama Carolina C Espinoza Jaime A JA Riquelme Ismael I Nervi Bruno B Araya Juan C JC Grez Manuel M Roa Juan C JC
Oncotarget 20151001 31
Gallbladder cancer (GBC) is a highly malignant tumor characterized by a poor response to chemotherapy and radiotherapy. We evaluated the in vitro and in vivo antitumor efficacy of mTOR inhibitors, rapamycin and WYE-354. In vitro assays showed WYE-354 significantly reduced cell viability, migration and invasion and phospho-P70S6K expression in GBC cells. Mice harboring subcutaneous gallbladder tumors, treated with WYE-354 or rapamycin, exhibited a significant reduction in tumor mass. A short-term ...[more]
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