Ontology highlight
ABSTRACT:
SUBMITTER: Jiang QW
PROVIDER: S-EPMC4741730 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Jiang Qi-Wei QW Cheng Ke-Jun KJ Mei Xiao-Long XL Qiu Jian-Ge JG Zhang Wen-Ji WJ Xue You-Qiu YQ Qin Wu-Ming WM Yang Yang Y Zheng Di-Wei DW Chen Yao Y Wei Meng-Ning MN Zhang Xu X Lv Min M Chen Mei-Wan MW Wei Xing X Shi Zhi Z
Oncotarget 20151001 32
Triptolide and celastrol are two main active compounds isolated from Thunder God Vine with the potent anticancer activity. However, the anticancer effect of triptolide in combination with celastrol is still unknown. In the present study, we demonstrated that the combination of triptolide with celastrol synergistically induced cell growth inhibition, cell cycle arrest at G2/M phase and apoptosis with the increased intracellular ROS accumulation in cancer cells. Pretreatment with ROS scavenger N-a ...[more]