Ontology highlight
ABSTRACT:
SUBMITTER: Alachkar H
PROVIDER: S-EPMC4741775 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Alachkar Houda H Mutonga Martin M Malnassy Gregory G Park Jae-Hyun JH Fulton Noreen N Woods Alex A Meng Liping L Kline Justin J Raca Gordana G Odenike Olatoyosi O Takamatsu Naofumi N Miyamoto Takashi T Matsuo Yo Y Stock Wendy W Nakamura Yusuke Y
Oncotarget 20151001 32
Gain-of-function mutations of FLT3 (FLT3-ITD), comprises up to 30% of normal karyotype acute myeloid leukemia (AML) and is associated with an adverse prognosis. Current FLT3 kinase inhibitors have been tested extensively, but have not yet resulted in a survival benefit and novel therapies are awaited. Here we show that T-LAK cell-originated protein kinase (TOPK), a mitotic kinase highly expressed in and correlated with more aggressive phenotype in several types of cancer, is expressed in AML but ...[more]