Ontology highlight
ABSTRACT:
SUBMITTER: Gu YJ
PROVIDER: S-EPMC4741793 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Gu Yan-jiao YJ Li Hong-dan HD Zhao Liang L Zhao Song S He Wu-bin WB Rui Li L Su Chang C Zheng Hua-chuan HC Su Rong-jian RJ
Oncotarget 20151001 32
5-FU is a common first-line chemotherapeutic drug for the treatment of hepatocellular carcinoma. However the development of acquired resistance to 5-FU confines its clinical usages. Although this phenomenon has been the subject of intense investigation, the exact mechanism of acquired resistance to 5-FU remains elusive. Here, we report that over-expression of GRP78 contributes to acquired resistance to 5-FU in HCC by up-regulating the c-Src/LSF/TS axis. Moreover, we found that the resistance to ...[more]