Ontology highlight
ABSTRACT:
SUBMITTER: Jamshidi M
PROVIDER: S-EPMC4741978 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Jamshidi Maral M Fagerholm Rainer R Khan Sofia S Aittomäki Kristiina K Czene Kamila K Darabi Hatef H Li Jingmei J Andrulis Irene L IL Chang-Claude Jenny J Devilee Peter P Fasching Peter A PA Michailidou Kyriaki K Bolla Manjeet K MK Dennis Joe J Wang Qin Q Guo Qi Q Rhenius Valerie V Cornelissen Sten S Rudolph Anja A Knight Julia A JA Loehberg Christian R CR Burwinkel Barbara B Marme Frederik F Hopper John L JL Southey Melissa C MC Bojesen Stig E SE Flyger Henrik H Brenner Hermann H Holleczek Bernd B Margolin Sara S Mannermaa Arto A Kosma Veli-Matti VM Van Dyck Laurien L Nevelsteen Ines I Couch Fergus J FJ Olson Janet E JE Giles Graham G GG McLean Catriona C Haiman Christopher A CA Henderson Brian E BE Winqvist Robert R Pylkäs Katri K Tollenaar Rob A E M RA García-Closas Montserrat M Figueroa Jonine J Hooning Maartje J MJ Martens John W M JW Cox Angela A Cross Simon S SS Simard Jacques J Dunning Alison M AM Easton Douglas F DF Pharoah Paul D P PD Hall Per P Blomqvist Carl C Schmidt Marjanka K MK Nevanlinna Heli H
Oncotarget 20151101 35
In breast cancer, constitutive activation of NF-κB has been reported, however, the impact of genetic variation of the pathway on patient prognosis has been little studied. Furthermore, a combination of genetic variants, rather than single polymorphisms, may affect disease prognosis. Here, in an extensive dataset (n = 30,431) from the Breast Cancer Association Consortium, we investigated the association of 917 SNPs in 75 genes in the NF-κB pathway with breast cancer prognosis. We explored SNP-SNP ...[more]