Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC4742173 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Oncotarget 20151101 34
MicroRNA (miRNA)-25 is a small non-coding RNA that has been implicated in the tumorigenesis of many cancers, but little is known on the role of miR-25 in HCC metastasis. We hereby found that miR-25 was significantly upregulated in clinical HCC tissues compared with normal liver tissues. We also revealed that miR-25 dramatically stimulates HCC cell growth and activates the epithelial-mesenchymal transition (EMT). MiR-25 is activated by the WNT/β-catenin signaling pathway, and exerts its pro-metas ...[more]