Ontology highlight
ABSTRACT:
SUBMITTER: Zhang CZ
PROVIDER: S-EPMC4742237 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Zhang Cheng-Zhong CZ Spektor Alexander A Cornils Hauke H Francis Joshua M JM Jackson Emily K EK Liu Shiwei S Meyerson Matthew M Pellman David D
Nature 20150527 7555
Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromothripsis is unknown, but we previously proposed that it could occur through the physical isolation of chromosomes in aberrant nuclear structures called micronuclei. Here, using a com ...[more]