Ontology highlight
ABSTRACT:
SUBMITTER: Cloonan SM
PROVIDER: S-EPMC4742374 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Cloonan Suzanne M SM Glass Kimberly K Laucho-Contreras Maria E ME Bhashyam Abhiram R AR Cervo Morgan M Pabón Maria A MA Konrad Csaba C Polverino Francesca F Siempos Ilias I II Perez Elizabeth E Mizumura Kenji K Ghosh Manik C MC Parameswaran Harikrishnan H Williams Niamh C NC Rooney Kristen T KT Chen Zhi-Hua ZH Goldklang Monica P MP Yuan Guo-Cheng GC Moore Stephen C SC Demeo Dawn L DL Rouault Tracey A TA D'Armiento Jeanine M JM Schon Eric A EA Manfredi Giovanni G Quackenbush John J Mahmood Ashfaq A Silverman Edwin K EK Owen Caroline A CA Choi Augustine M K AM
Nature medicine 20160111 2
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility gene and have shown that IRP2 protein is increased in the lungs of individuals with COPD. Here we demonstrate that mice deficient in Irp2 were protected from cigarette smoke (CS)-induced experimental COPD. By integrating RNA immunoprecipitation followed by sequencing (RIP-seq), ...[more]