Ontology highlight
ABSTRACT:
SUBMITTER: Fulciniti M
PROVIDER: S-EPMC4742623 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Fulciniti M M Amodio N N Bandi R L RL Cagnetta A A Samur M K MK Acharya C C Prabhala R R D'Aquila P P Bellizzi D D Passarino G G Adamia S S Neri A A Hunter Z R ZR Treon S P SP Anderson K C KC Tassone P P Munshi N C NC
Blood cancer journal 20160115
Deregulated microRNA (miR)/transcription factor (TF)-based networks represent a hallmark of cancer. We report here a novel c-Myc/miR-23b/Sp1 feed-forward loop with a critical role in multiple myeloma (MM) and Waldenstrom's macroglobulinemia (WM) cell growth and survival. We have found miR-23b to be downregulated in MM and WM cells especially in the presence of components of the tumor bone marrow milieu. Promoter methylation is one mechanism of miR-23b suppression in myeloma. In gain-of-function ...[more]