Ontology highlight
ABSTRACT:
SUBMITTER: Hilbers F
PROVIDER: S-EPMC4742777 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Hilbers Florian F Kopec Wojciech W Isaksen Toke Jost TJ Holm Thomas Hellesøe TH Lykke-Hartmann Karin K Nissen Poul P Khandelia Himanshu H Poulsen Hanne H
Scientific reports 20160205
The vital gradients of Na(+) and K(+) across the plasma membrane of animal cells are maintained by the Na,K-ATPase, an αβ enzyme complex, whose α subunit carries out the ion transport and ATP hydrolysis. The specific roles of the β subunit isoforms are less clear, though β2 is essential for motor physiology in mammals. Here, we show that compared to β1 and β3, β2 stabilizes the Na(+)-occluded E1P state relative to the outward-open E2P state, and that the effect is mediated by its transmembrane d ...[more]