Epigenetic re-expression of HIF-2? suppresses soft tissue sarcoma growth.
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ABSTRACT:
SUBMITTER: Nakazawa MS
PROVIDER: S-EPMC4742834 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth.
Nakazawa Michael S MS Eisinger-Mathason T S Karin TS Sadri Navid N Ochocki Joshua D JD Gade Terence P F TP Amin Ruchi K RK Simon M Celeste MC
Nature communications 20160203
In soft tissue sarcomas (STS), low intratumoural O2 (hypoxia) is a poor prognostic indicator. HIF-1α mediates key transcriptional responses to hypoxia, and promotes STS metastasis; however, the role of the related HIF-2α protein is unknown. Surprisingly, here we show that HIF-2α inhibits high-grade STS cell growth in vivo, as loss of HIF-2α promotes sarcoma proliferation and increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma. We find ...[more]
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