Ontology highlight
ABSTRACT:
SUBMITTER: Nayak A
PROVIDER: S-EPMC4742869 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nayak Anmada A Satapathy Shakti Ranjan SR Das Dipon D Siddharth Sumit S Tripathi Neha N Bharatam Prasad V PV Kundu ChanakyaNath C
Scientific reports 20160205
To improve the pharmacokinetics and to study the anti-cervical cancer and anti-stem cells (CSCs) mechanism of Quinacrine (QC), a spherical nano particle of QC (i.e. NQC) was prepared and characterized. QC and NQC showed higher cytotoxicity in multiple cancer cells than the normal epithelial cells. NQC exhibited more toxicity in cervical cancer cells and its CSCs than QC. A dose-dependent decreased expression of Hedgehog-GLI (HH-GLI) components were noted in NQC treated HeLa cells and its CSCs. N ...[more]