Ontology highlight
ABSTRACT:
SUBMITTER: Melero R
PROVIDER: S-EPMC4743010 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Melero Roberto R Hug Nele N López-Perrote Andrés A Yamashita Akio A Cáceres Javier F JF Llorca Oscar O
Nature communications 20160204
Nonsense-mediated decay (NMD) is a messenger RNA quality-control pathway triggered by SMG1-mediated phosphorylation of the NMD factor UPF1. In recent times, the RNA helicase DHX34 was found to promote mRNP remodelling, leading to activation of NMD. Here we demonstrate the mechanism by which DHX34 functions in concert with SMG1. DHX34 comprises two distinct structural units, a core that binds UPF1 and a protruding carboxy-terminal domain (CTD) that binds the SMG1 kinase, as shown using truncated ...[more]