Ontology highlight
ABSTRACT:
SUBMITTER: Tai DJ
PROVIDER: S-EPMC4743023 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Tai Derek J C DJ Liu Yen C YC Hsu Wei L WL Ma Yun L YL Cheng Sin J SJ Liu Shau Y SY Lee Eminy H Y EH
Nature communications 20160204
The methyl-CpG-binding protein 2 (MeCP2) gene, MECP2, is an X-linked gene encoding the MeCP2 protein, and mutations of MECP2 cause Rett syndrome (RTT). However, the molecular mechanism of MECP2-mutation-caused RTT is less known. Here we find that MeCP2 could be SUMO-modified by the E3 ligase PIAS1 at Lys-412. MeCP2 phosphorylation (at Ser-421 and Thr-308) facilitates MeCP2 SUMOylation, and MeCP2 SUMOylation is induced by NMDA, IGF-1 and CRF in the rat brain. MeCP2 SUMOylation releases CREB from ...[more]