Ontology highlight
ABSTRACT:
SUBMITTER: Capell BC
PROVIDER: S-EPMC4743061 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Capell Brian C BC Drake Adam M AM Zhu Jiajun J Shah Parisha P PP Dou Zhixun Z Dorsey Jean J Simola Daniel F DF Donahue Greg G Sammons Morgan M Rai Taranjit Singh TS Natale Christopher C Ridky Todd W TW Adams Peter D PD Berger Shelley L SL
Genes & development 20160201 3
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the senescence-associated secretory phenotype (SASP). Previous observations link the transcription-associated methyltransferase and oncoprotein MLL1 to the DDR, leading us to investigate the role of MLL1 in ...[more]