Dataset Information

No Association of ApoE Genotype with Risk of Prostate Cancer: A Nested Case-Control Study.

ABSTRACT: Previous studies found that low total cholesterol level was associated with a lower risk of high-grade prostate cancer. Apolipoprotein E (ApoE) isoform is associated with total cholesterol level. The aim of this study was to explore associations of ApoE isoforms with prostate cancer risk.We assessed ApoE genotypes and risk of prostate cancer in a prospective case-control study nested among men who provided a blood sample in 1993-95 within the Health Professionals Follow-up Study. We identified 1,169 incident cases of prostate cancer and 1,233 controls in follow-up through 2004. Associations of ApoE isoform and prostate cancer incidence were evaluated by logistic regression models.We found no statistically significant associations of ApoE variants with overall prostate cancer or Gleason sum ? 7 (3+4), Gleason sum ? 7 (4+3), clinically localized stage, or progression to metastasis or death. There was no evidence of effect modification by circulating total cholesterol or use of cholesterol-lowering drugs prior to diagnosis.ApoE variants were not associated with the risk of prostate cancer or aggressive disease.Our findings suggest that the mechanism of circulating cholesterol level affecting prostate cancer incidence may not rely on ApoE isoforms.

SUBMITTER: Liu H

PROVIDER: S-EPMC4743244 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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No Association of ApoE Genotype with Risk of Prostate Cancer: A Nested Case-Control Study.

Liu Hui H Shui Irene M IM Platz Elizabeth A EA Mucci Lorelei A LA Giovannucci Edward L EL

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20150719 10

<h4>Background</h4>Previous studies found that low total cholesterol level was associated with a lower risk of high-grade prostate cancer. Apolipoprotein E (ApoE) isoform is associated with total cholesterol level. The aim of this study was to explore associations of ApoE isoforms with prostate cancer risk.<h4>Methods</h4>We assessed ApoE genotypes and risk of prostate cancer in a prospective case-control study nested among men who provided a blood sample in 1993-95 within the Health Professiona ...[more]

PMID: 26189769

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Project description:BackgroundVitamin E compounds exhibit prostate cancer preventive properties experimentally, but serologic investigations of tocopherols, and randomized controlled trials of supplementation in particular, have been inconsistent. Many studies suggest protective effects among smokers and for aggressive prostate cancer, however.MethodsWe conducted a nested case-control study of serum ?-tocopherol and ?-tocopherol and prostate cancer risk in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, with 680 prostate cancer cases and 824 frequency-matched controls. Multivariate-adjusted, conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs) for tocopherol quintiles.ResultsSerum ?-tocopherol and ?-tocopherol were inversely correlated (r?=?-0.24, p<0.0001). Higher serum ?-tocopherol was associated with significantly lower prostate cancer risk (OR for the highest vs. lowest quintile?=?0.63, 95% CI 0.44-0.92, p-trend 0.05). By contrast, risk was non-significantly elevated among men with higher ?-tocopherol concentrations (OR for the highest vs. lowest quintile?=?1.35, 95% CI 0.92-1.97, p-trend 0.41). The inverse association between prostate cancer and ?-tocopherol was restricted to current and recently former smokers, but was only slightly stronger for aggressive disease. By contrast, the increased risk for higher ?-tocopherol was more pronounced for less aggressive cancers.ConclusionsOur findings indicate higher ?-tocopherol status is associated with decreased risk of developing prostate cancer, particularly among smokers. Although two recent controlled trials did not substantiate an earlier finding of lower prostate cancer incidence and mortality in response to supplementation with a relatively low dose of ?-tocopherol, higher ?-tocopherol status may be beneficial with respect to prostate cancer risk among smokers. Determining what stage of prostate cancer development is impacted by vitamin E, the underlying mechanisms, and how smoking modifies the association, is needed for a more complete understanding of the vitamin E-prostate cancer relation.

Dataset Information

No Association of ApoE Genotype with Risk of Prostate Cancer: A Nested Case-Control Study.

Publications

No Association of ApoE Genotype with Risk of Prostate Cancer: A Nested Case-Control Study.

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