Ontology highlight
ABSTRACT:
SUBMITTER: Prachayasittikul V
PROVIDER: S-EPMC4743480 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Prachayasittikul Veda V Worachartcheewan Apilak A Shoombuatong Watshara W Prachayasittikul Virapong V Nantasenamat Chanin C
EXCLI journal 20150819
P-glycoprotein (Pgp) is a drug transporter that plays important roles in multidrug resistance and drug pharmacokinetics. The inhibition of Pgp has become a notable strategy for combating multidrug-resistant cancers and improving therapeutic outcomes. However, the polyspecific nature of Pgp, together with inconsistent results in experimental assays, renders the determination of endpoints for Pgp-interacting compounds a great challenge. In this study, the classification of a large set of 2,477 Pgp ...[more]